SEP 7, 2026 · JOURNAL ARTICLE
Estrogen promotes tumor phenotypes in ER+ and ER– breast cancer through UGDH-GPR30
Jci Insight
This is a mechanistic study using cell lines, animal models, and patient specimens to explore a signaling pathway; it raises questions about UGDH/GPR30 in estrogen-responsive breast cancer but does not report clinical outcomes or hard endpoints that would support practice change.
Study details
DesignIn vitro cell-line study, in vivo xenograft…
InterventionEstrogen stimulation; UGDH genetic knockdown
ComparatorUnstimulated controls or wild-type (non-kno…