Human Gene Therapy

AUG 23, 2026 · JOURNAL ARTICLE

Triple-Target CRISPR Strategy to Block HIV Entry and Replication in Permissive Cells

Human Gene Therapy

Early-stage in vitro and ex vivo proof-of-concept work demonstrating a novel triple-target CRISPR strategy, not yet tested in vivo or clinically, with no efficacy or safety data in human subjects.

JUL 27, 2026 · JOURNAL ARTICLE

Restoring Cancer Genomes: Functional Mutation Correction as a Platform for Precision Oncology

Human Gene Therapy

A perspective article proposing a conceptual framework for using CRISPR-based mutation correction to interrogate cancer drivers; raises mechanistic and therapeutic questions rather than presenting experimental evidence or clinical outcomes.

JUL 26, 2026 · JOURNAL ARTICLE

Systematic Benchmarking of CRISPR-Cas9 Off-Target Prediction Tools Reveals Limitations and Implications for Preclinical Assessment

Human Gene Therapy

A systematic benchmarking study of computational tools against experimental data, showing moderate performance with substantial limitations; informs preclinical practice but does not establish a new clinical standard or definitive tool ranking.