Human Gene Therapy

OCT 14, 2026 · JOURNAL ARTICLE

Beyond Viruses: Transposons and CRISPR-Programmable Nonviral Systems for Genome Engineering

Human Gene Therapy

Human gene therapy has been transformed by repurposing mobile genetic elements as tools for efficient gene delivery and precise genome modification. Viruses, transposons, and retro

OCT 8, 2026 · JOURNAL ARTICLE

Automated Production of Gene-Edited CAR-T Cells for People Living with HIV

Human Gene Therapy

Adoptive transfer of gene-modified autologous T cells, for example, expressing chimeric antigen receptors (CARs), is a promising therapy option for a variety of malignant and nonma

AUG 23, 2026 · JOURNAL ARTICLE

Triple-Target CRISPR Strategy to Block HIV Entry and Replication in Permissive Cells

Human Gene Therapy

Early-stage in vitro and ex vivo proof-of-concept work demonstrating a novel triple-target CRISPR strategy, not yet tested in vivo or clinically, with no efficacy or safety data in human subjects.

JUL 27, 2026 · JOURNAL ARTICLE

Restoring Cancer Genomes: Functional Mutation Correction as a Platform for Precision Oncology

Human Gene Therapy

A perspective article proposing a conceptual framework for using CRISPR-based mutation correction to interrogate cancer drivers; raises mechanistic and therapeutic questions rather than presenting experimental evidence or clinical outcomes.

JUL 26, 2026 · JOURNAL ARTICLE

Systematic Benchmarking of CRISPR-Cas9 Off-Target Prediction Tools Reveals Limitations and Implications for Preclinical Assessment

Human Gene Therapy

A systematic benchmarking study of computational tools against experimental data, showing moderate performance with substantial limitations; informs preclinical practice but does not establish a new clinical standard or definitive tool ranking.