Genomics and Rare Diseases

SEP 8, 2026 · REVIEW

Economic evaluations of next-generation sequencing for targeted therapy in non-small cell lung cancer: a systematic review

Frontiers in Public Health

Systematic review of economic evidence synthesizing 18 model-based evaluations to inform policy on NGS adoption in NSCLC, with contextual conclusions about cost-effectiveness variability rather than a single definitive clinical or economic finding.

AUG 31, 2026 · JOURNAL ARTICLE

The SARS-CoV-2 Integrated Genomic Epidemiology Database (IGED): Linking viral genomes with patient-level metadata to advance statewide genomic surveillance in California

PLOS Digital Health

This is a descriptive implementation report of a state surveillance database system, not a hypothesis test or clinical trial; it documents infrastructure development and data integration feasibility without measuring a clinical or public health intervention outcome.

AUG 18, 2026 · JOURNAL ARTICLE

Modeling KRAS mutations in KMT2A::MLLT3 acute myeloid leukemia promotes leukemic progression and transcriptional rewiring

Leukemia

A mechanistic preclinical model study with supporting clinical cohort data showing KRAS mutations accelerate KMT2A::MLLT3 AML progression; limited by in vivo mouse model design and observational patient data without controlled comparison.

AUG 18, 2026 · JOURNAL ARTICLE

Quantum technologies in clinical medicine: a systematic cross-domain synthesis and translational readiness taxonomy

Journal of King Saud University - Computer and Information Sciences

A systematic literature review and taxonomy framework mapping quantum technology maturity across clinical domains, but with no primary clinical trial data, patient outcomes, or prospective validation—descriptive synthesis only.

AUG 14, 2026 · JOURNAL ARTICLE

Precision Medicine in patients with rare forms of genetic obesity: Necessity for coordinated and structured care

The Journal of Clinical Endocrinology & Metabolism

European expert consensus recommendation for structured care and centres of expertise in rare monogenic obesity, addressing diagnosis, access, and monitoring for newly approved MC4R agonist therapies.

AUG 13, 2026 · JOURNAL ARTICLE

Genomic alterations in pediatric tumors: clinical relevance and translational insights

Pediatric Research

Single-centre retrospective analysis of modest sample with descriptive findings and no control group; clinical utility claimed but outcomes data not quantified, making it exploratory rather than confirmatory.

AUG 12, 2026 · JOURNAL ARTICLE

fourSynergy: ensemble-based interaction calling on 4C-seq data using gradient-free optimization

Biodata Mining

A methodological study demonstrating an ensemble algorithm for chromatin interaction detection with improved computational performance metrics, but lacking clinical validation, prospective application, or comparison to gold-standard experimental confirmation.

JUL 31, 2026 · JOURNAL ARTICLE

Bridging human genetics and community medicine: emerging applications for precision public health

International Journal of Community Medicine and Public Health

A narrative review synthesizing evidence and expert perspectives on integrating genomics into public health practice, with discussion of implementation frameworks rather than reporting new empirical results.