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Diabetes, Cardiovascular Risks, and Lipoproteins · Journal article
Journal of Biostatistics and Epidemiology · September 4, 2026
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This cross-sectional baseline study reports a 23.50% prevalence of metabolic syndrome among 5,903 healthcare workers at a single Iranian medical centre, with abdominal obesity as the most common component (50.5%) and underlying medical disease as a significant univariable and multivariable correlate (aPR 1.94, 95% CI 1.75–2.15, p<0.001). The absence of a comparator group and cross-sectional design preclude causal inference or assessment of whether prevalence differs meaningfully from non-healthcare populations.
Cross-sectional baseline cohort study. Healthcare workers enrolled in the Shiraz University of Medical Sciences Employees Health Cohort Study (SUMS EHCS), a branch of the PERSIAN cohort study in South of Iran.. n = 5,903. Shiraz University of Medical Sciences, South of Iran..
Prevalence of metabolic syndrome was 23.50% in the cohort. Abdominal obesity was the most common component at 50.5%. Underlying diseases were significantly associated with metabolic syndrome in multivariable analysis (aPR = 1.94 [95% CI: 1.75, 2.15]; P < 0.001).
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The finding does not establish causation or identify modifiable prevention strategies; the lack of association with lifestyle factors and absence of a comparator group limit actionability. Clinicians should note that underlying medical conditions appear correlated with metabolic syndrome in this workforce, but prospective follow-up and between-group comparisons are needed before tailored interventions for healthcare workers can be recommended.
Cross-sectional baseline cohort study with descriptive prevalence data and associations, but no intervention, no comparator group, and no causal inference; suitable for hypothesis generation rather than clinical decision-making.
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The finding does not establish causation or identify modifiable prevention strategies; the lack of association with lifestyle factors and absence of a comparator group limit actionability. Clinicians should note that underlying medical conditions appear correlated with metabolic syndrome in this workforce, but prospective follow-up and between-group comparisons are needed before tailored interventions for healthcare workers can be recommended.
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Introduction: Shift work, a characteristic of healthcare workers' jobs, is recognized as a contributing factor to various health conditions, particularly metabolic syndrome. However, the risk of this medical condition is still understudied among shift workers in the healthcare sector. This study investigated metabolic syndrome and its components in the "Shiraz University of Medical Sciences Employees Health Cohort Study" (SUMS EHCS), a branch of the PERSIAN cohort study in the south of Iran. Methods: This cross-sectional study utilized baseline data from 5,903 participants in the SUMS EHCS. The ATP III criteria were applied to diagnose metabolic syndrome, which requires the evated triglycerides, low HDL cholesterol, high blood pressure, and elevated fasting plasma glucose. Statistical analyses were conducted using Poisson regression models and STATA software. Results: The prevalence of metabolic syndrome was 23.50%, with abdominal obesity identified as the most common component (50.5%). The presence of underlying diseases was significantly associated with the diagnosis of metabolic syndrome in both univariable (prevalence ratio (PR) = 1.93 [95% confidence interval (CI): 1.74, 2.14]; P < 0.001) and multivariable analyses (adjusted PR (aPR) = 1.94 [95% CI: 1.75, 2.15]; P < 0.001). No significant association was found between modifiable lifestyle factors and metabolic syndrome (P > 0.05). Conclusion:The similar prevalence of metabolic syndrome in healthcare workers compared to the general population highlights the need for similar preventive and curative health strategies, particularly focusing on underlying medical conditions to improve the metabolic health of healthcare workers.
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