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Diabetes, Cardiovascular Risks, and Lipoproteins · Journal article
Journal of Back and Musculoskeletal Rehabilitation · August 6, 2026
Encouraging direction, but not yet definitive.
This cross-sectional analysis of 11,319 U.S. adults from NHANES (2011–2016) reports independent associations between elevated AIP and CMI with osteoarthritis risk after adjustment, with dose-response relationships identified. The work is observational and cannot establish causation, but the large sample and stratified analysis suggest associations warrant prospective validation.
Cross-sectional study. U.S. adults from NHANES 2011–2016 with complete anthropometric and osteoarthritis data.. Intervention: Abdominal obesity indices: ABSI, AIP, CMI. Compared with: Osteoarthritis diagnosis. n = 11,319. United States (NHANES survey).
AIP independently associated with OA: OR = 1.36 (after full adjustment) CMI independently associated with OA: OR = 1.55 (after full adjustment) AIP showed linear positive association with OA; CMI showed inverted U-shaped association
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
Clinicians may consider AIP and CMI as supplementary abdominal obesity markers for osteoarthritis risk stratification in younger and middle-aged adults, particularly non-Hispanic white populations, but the cross-sectional design means this should guide hypothesis generation or personalized counselling, not clinical decision-making, until prospective evidence accrues.
A cross-sectional study of adequate size identifies independent associations between abdominal obesity indices and osteoarthritis with dose-response analysis, but cannot establish causation and relies on surrogate anthropometric measures rather than hard clinical outcomes.
As stated by the source record.
Quoted from the source exactly as published.
Clinicians may consider AIP and CMI as supplementary abdominal obesity markers for osteoarthritis risk stratification in younger and middle-aged adults, particularly non-Hispanic white populations, but the cross-sectional design means this should guide hypothesis generation or personalized counselling, not clinical decision-making, until prospective evidence accrues.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
BackgroundObesity is an established independent risk factor for osteoarthritis (OA). BMI cannot reflect fat distribution, while abdominal obesity is more closely related to OA. ABSI, AIP, and CMI are novel abdominal obesity indices with good predictive performance, but their associations with OA remain unclear.ObjectiveTo explore the independent associations of ABSI, AIP, CMI with OA risk in U.S. adults, clarify dose-response relationships, and compare their predictive ability.MethodsThis cross-sectional study included 11,319 participants from NHANES 2011-2016. Weighted logistic regression, RCS, subgroup analysis, and ROC analysis were applied.ResultsAfter full adjustment, elevated AIP and CMI were independently associated with higher OA risk (AIP: OR = 1.36; CMI: OR = 1.55). AIP showed a linear positive association, and CMI had an inverted U-shaped association with OA. ABSI showed no significant association. The associations were stronger in adults ≤60 years and non-Hispanic white individuals. ABSI had the highest AUC (0.637).ConclusionElevated AIP and CMI are independently associated with OA, modified by age and ethnicity. AIP and CMI can be used for OA risk stratification in young and middle-aged adults with abdominal obesity and metabolic disorders.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.