Cancer Related Gene Regulation

SEP 5, 2026 · JOURNAL ARTICLE

PRMT7 restricts CD8+ T cells expansion via the NF-ΚB pathway

Nature Communications

A mechanistically sound study combining genetic and pharmacological approaches in mouse and human models, demonstrating PRMT7 inhibition enhances CD8+ T cell function, but limited by single tumor model and lack of phase-controlled clinical trial.

AUG 26, 2026 · JOURNAL ARTICLE

Methylation Mesa define functional regulatory elements for targeted gene activation

Nature Communications

This is a mechanistic discovery study identifying a novel epigenetic element class (Methylation Mesa) and demonstrating proof-of-concept that targeted demethylation drives gene activation in cell models, but lacks clinical endpoint data or confirmatory independent validation.

AUG 18, 2026 · JOURNAL ARTICLE

ERα36 is associated with SLC7A5/LAT1 expression, cervical cancer progression, and BNCT response: a translational study

Frontiers in Oncology

Translational study combining transcriptomic analysis, tissue immunofluorescence, and in vitro/in vivo cell models to characterize a signaling axis; lacks clinical trial evidence of BNCT response prediction or prognostic validation.

AUG 17, 2026 · JOURNAL ARTICLE

DNA methylation modulation by 5-Azacytidine regulates EMT markers and reduces invasiveness in docetaxel-resistant prostate cancer cells

Scientific Reports

In vitro mechanistic study in cancer cell lines demonstrating that DNMT1 inhibition modulates EMT markers and reduces invasiveness in docetaxel-resistant prostate cancer, but lacks in vivo validation, clinical endpoints, or human data.

AUG 12, 2026 · JOURNAL ARTICLE

Gene Variations in RNA Modification Pathway Linked to Poor Survival After Gastric Cancer Surgery

Genes

Retrospective cohort study with appropriate statistical methods and hard clinical endpoints (overall and disease-free survival) showing independent associations between m6A genetic variants and poor prognosis after gastrectomy, but limited by single-centre design, retrospective conduct, and lack of external validation.

AUG 1, 2026 · JOURNAL ARTICLE

DNA Hypomethylation Is Not Cell Intrinsically Toxic to Polycomb Repressive Complex 2 Deficient Malignant Peripheral Nerve Sheath Tumors

Genes Chromosomes and Cancer

In vitro mechanistic study in cell lines and engineered cells examining epigenetic mechanisms in MPNSTs; demonstrates proof-of-concept but lacks in vivo validation or clinical data.