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A systematic review synthesizing retrospective and prospective evidence to inform clinical decision-making about locoregional surgery in de-novo stage IV breast cancer, concluding routine surgery is not recommended except for bone-only metastases.
Translational study combining transcriptomic analysis, tissue immunofluorescence, and in vitro/in vivo cell models to characterize a signaling axis; lacks clinical trial evidence of BNCT response prediction or prognostic validation.
This is an unrefereed arXiv preprint describing a novel machine learning algorithm for model merging; it presents a technical method with experimental comparisons but has not undergone peer review.
This is an unreviewed systems engineering paper demonstrating a runtime optimization technique with reported speedup metrics, but lacks clinical or scientific validation, ground-truth comparison, or peer review.
Single-centre feasibility study with small sample (n=20) and surrogate endpoints (dosimetric indices); demonstrates technical capability but lacks hard clinical outcomes or patient data.