SEP 7, 2026 · JOURNAL ARTICLE
Advances in locoregional surgical treatment of de-novo stage IV breast cancer: a review
Frontiers in Oncology
A systematic review synthesizing retrospective and prospective evidence to inform clinical decision-making about locoregional surgery in de-novo stage IV breast cancer, concluding routine surgery is not recommended except for bone-only metastases.
Study details
DesignSystematic review of retrospective cohort s…
InterventionLocoregional (primary tumor) surgical resec…
ComparatorSystemic therapy alone (primary systemic th…