Peroxisome Proliferator-activated Receptors

SEP 7, 2026 · JOURNAL ARTICLE

Oxidative Stress as a Pathophysiological Core of Obesity: Preclinical Evidence for Antioxidant-Based Therapy Strategies

Pharmaceuticals

A narrative review of preclinical evidence proposing a mechanistic theory (oxidative stress as pathophysiological core) and surveying diverse interventions without new primary data, clinical trials, or human outcome evidence.

SEP 5, 2026 · JOURNAL ARTICLE

Targeting the Fatty Acid Binding Protein 5–Specificity Protein 1 Axis Restores Enzalutamide Sensitivity by Suppressing Androgen Receptor/Androgen Receptor Splice Variant 7 Signaling: Implications for Prostate Cancer Therapy

World Journal of Oncology

Mechanistic study in cell culture identifying a putative regulatory axis; lacks clinical validation, patient outcomes, or prospective testing needed to support therapeutic claims.

AUG 24, 2026 · JOURNAL ARTICLE

Integrated multi-omics analysis and functional experiments reveals PPAP2C as a potential prognostic biomarker and therapeutic target in breast cancer

Frontiers in Pharmacology

Integrative multi-omics study with confirmatory survival analyses across multiple cohorts and mechanistic validation in TNBC cells and xenografts, but lacks clinical trial evidence and therapeutic efficacy data in vivo.

AUG 18, 2026 · JOURNAL ARTICLE

A Framework for Selecting Zebrafish Models of Metabolic Diseases: Modeling Strategies, Phenotypic Validation, Mechanistic Investigation, and Efficacy Evaluation

Biomedicines

This is a consensus framework review proposing evidence-based criteria for selecting and validating zebrafish models of metabolic disease, intended to standardize research practice and improve translational reliability.

AUG 18, 2026 · JOURNAL ARTICLE

Taurine and Metabolic Diseases: Molecular Mechanisms and Therapeutic Implications

Food Frontiers

This is a narrative review synthesizing preclinical evidence and mechanistic hypotheses about taurine's role in metabolic disease, without reporting original clinical trial data or meta-analytic quantification of effect.

AUG 6, 2026 · JOURNAL ARTICLE

Effect of Combined Grape Seed (Vitis vinifera) and Garlic (Allium sativum) Extracts on Adipogenesis in the 3T3-L1 Preadipocyte Line

International Journal of Molecular Sciences

In vitro mechanistic study in a preadipocyte cell line with no animal or human validation; demonstrates differential effects on lipid accumulation and gene expression but lacks clinical relevance and independent replication.