Angiogenesis and VEGF in Cancer

SEP 10, 2026 · REVIEW

Intra- and intertumoral discordance of Claudin-18.2: a systematic review and meta-analysis

ESMO Gastrointestinal Oncology

Rigorous meta-analysis of 25 studies with adequate pooled sample sizes quantifies clinically meaningful spatial heterogeneity in Claudin-18.2 expression, with clear implications for specimen selection in targeted therapy decisions.

SEP 10, 2026 · REVIEW

Role of hypoxia-inducible factor – 1 alpha on the progression of cervical intraepithelial neoplasia and cervical cancer: a narrative review

Frontiers in Oncology

A narrative review synthesizing mechanistic evidence and experimental findings on HIF-1α in cervical cancer progression, raising questions about therapeutic targets rather than reporting clinical trial outcomes or definitive clinical evidence.

SEP 9, 2026 · JOURNAL ARTICLE

Venous Thromboembolism in Patients Receiving Vascular Endothelial Growth Factor-Targeted Therapy

Journal of Vascular Diseases

A comprehensive narrative review synthesizing evidence from trials, observational studies, and pharmacovigilance to provide clinical guidance on VTE risk, mechanisms, and management in VEGF-inhibitor-treated patients.

SEP 4, 2026 · JOURNAL ARTICLE

Restoration of tumor vascular integrity by P188 improves chemotherapy and immunotherapy efficacy in triple negative breast cancer

Biomedicine & Pharmacotherapy

A sound preclinical study combining in vitro and in vivo work in a mouse TNBC model, demonstrating mechanistic plausibility and efficacy enhancement, but lacking human data, clinical endpoints, or direct comparison to standard anti-angiogenic therapy.

SEP 4, 2026 · JOURNAL ARTICLE

Benmelstobart plus antiangiogenic therapy vs chemotherapy for metastatic triple-negative breast cancer: phase III trial

npj Breast Cancer

Underpowered trial prematurely stopped at 46% of planned enrollment with non-significant primary endpoint; efficacy analyses explicitly stated as exploratory, requiring cautious interpretation.

AUG 14, 2026 · JOURNAL ARTICLE

Single-cell and spatial transcriptomics define the LAMC2+ malignant subtype orchestrating vasculogenic mimicry-mediated resistance in head and neck cancer

npj Precision Oncology

Mechanistic study using transcriptomics and experimental models to propose a resistance pathway; lacks clinical trial evidence or outcome validation of the proposed therapeutic strategy.

AUG 14, 2026 · JOURNAL ARTICLE

Nitric Oxide in Cancer: Mechanisms, Dual Role, and Therapeutic Strategies

Medcomm – Oncology

A narrative review synthesizing mechanistic concepts and therapeutic strategies without presenting primary empirical data, clinical trials, or meta-analyses; raises questions about NO-based cancer interventions rather than testing them.

AUG 11, 2026 · JOURNAL ARTICLE

Molecular Mechanisms of Vasculogenesis in Human Cancers: From Developmental Pathways to Tumor Vascular Remodeling and Therapeutic Targeting

Biology

This is a narrative mechanistic review synthesizing literature on tumor vasculogenesis pathways; it raises questions about therapeutic targeting rather than testing a specific hypothesis through empirical study.