Chemotherapy-induced Cardiotoxicity and Mitigation
35 developments in the corpus
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European Heart Journal - Valvular and Structural Heart Disease
A multidisciplinary consensus position paper providing evidence-based suggestions for managing severe valvular heart disease in active cancer patients, without reporting original trial data.
A descriptive comparative analysis of guideline recommendations, utilization patterns, and research directions without primary efficacy or safety outcome data; provides context on current practice but no new clinical evidence.
A single-centre observational cohort study with surrogate ECG endpoints and modest sample size (n=291) examining QTc changes during cancer therapy; findings on QTc prolongation risk are descriptive and hypothesis-generating rather than practice-changing.
A comprehensive narrative review synthesizing evidence from trials, observational studies, and pharmacovigilance to provide clinical guidance on VTE risk, mechanisms, and management in VEGF-inhibitor-treated patients.
A retrospective single-centre study of 486 patients demonstrating that a three-biomarker panel outperforms existing risk scores for a surrogate endpoint (serum creatinine change), with clear effect sizes but requiring prospective validation and generalization to cardio-oncology populations.
This is a rationale-and-design paper for a small, single-centre RCT that has not yet reported results; it describes planned methods and hypotheses rather than outcomes.
A retrospective nomogram development and validation study in a single centre with good discrimination metrics (AUROC 0.901) and internal validation, but based on a surrogate endpoint (elevated troponin) rather than hard clinical outcomes, limiting generalizability.
A Scientific Statement outlining quality standards and best practices for preclinical cardio-oncology research, intended to promote standardization, reproducibility, and rigor in the field.