Following this puts new work involving it at the top of your briefing, with a note saying why it is there. Links are taken from the source record, never inferred.
A well-designed cross-sectional study dissecting independent and interactive effects of obesity and COVID-19 severity on immune mediators and cell populations, with rigorous statistical approach, but limited by lack of longitudinal follow-up, hard clinical outcomes, or external validation of biomarker utility.
Single animal model study with mechanistic endpoints and no human data; demonstrates proof-of-concept for anti-obesity effects but requires confirmation in human trials before clinical application.
Systematic review and network meta-analysis of 60 RCTs with prespecified methodology, confidence assessment, and consistent directness to inflammatory biomarkers in the target population, though based on surrogate endpoints rather than clinical outcomes.
A single-centre observational study with serial biomarker measurements demonstrating a clear association between residual inflammatory risk and clinical outcomes in post-MI patients, but lacking a randomized design or intervention to establish causation or guide treatment.
Cross-sectional observational study with clear associations between inflammatory biomarkers and obesity in a defined population, but cross-sectional design precludes causal inference and generalizability beyond Southwest Nigeria is uncertain.
This is a narrative review synthesizing mechanistic pathways rather than reporting new empirical evidence; it raises questions about immune dysregulation linking obesity to GDM but does not present primary data or definitive evidence to answer them.
Journal of Integrative and Translational Biomedicine
In vitro cell culture study showing mechanistic effects on lipid metabolism without clinical outcomes, efficacy data, or in vivo validation; raises questions about therapeutic potential rather than answering them.
Journal of Food Innovation, Nutrition, and Environmental Sciences
A narrative review synthesizing mechanistic knowledge of immune-cell roles in obesity-related inflammation; raises questions for future research rather than presenting new empirical evidence or testing interventions.