Magnetic Resonance Imaging

SEP 4, 2026 · PHASE 3 TRIAL

Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial

ClinicalTrials.gov

This is an actively recruiting Phase 3 trial with no results posted; the registry record describes planned design and enrollment only, with no outcome data available for assessment.

AUG 18, 2026 · JOURNAL ARTICLE

Bridging brain structures and adolescent depression and anxiety symptoms: A symptom-oriented approach.

Journal of Affective Disorders

Cross-sectional network analysis of brain structure and self-reported symptoms in adolescents, identifying associations without establishing causation, clinical outcomes, or intervention efficacy.

AUG 17, 2026 · JOURNAL ARTICLE

Domain adversarial transfer graph deep learning: A cross-site MDD fMRI data analysis framework.

Psychiatry Research. Neuroimaging

A methodological development study demonstrating a machine learning framework for depression classification using multi-site fMRI data, with validation on external data but no clinical outcome measure or direct comparison to clinical diagnosis.

AUG 5, 2026 · JOURNAL ARTICLE

Apoptosis protein markers in comorbid type 2 diabetes mellitus and depression; relationships with cognitive performance, incident dementia, and white matter hyperintensities.

Journal of Affective Disorders

A large retrospective cohort study identifying novel proteomic markers associated with dementia risk in comorbid T2DM and MDD, with clear statistical associations but requiring prospective validation and mechanistic confirmation.

JUL 25, 2026 · JOURNAL ARTICLE

Trajectories of sleep disturbance in older adults and their associations with clinical and pathological outcomes in AD: A longitudinal study.

Sleep Medicine

Rigorous longitudinal cohort study with 774 participants, 8-year follow-up, validated trajectory modeling, and multiple biomarker endpoints showing clear associations between sleep disturbance patterns and incident AD risk with strong effect sizes.

MAY 30, 2026 · JOURNAL ARTICLE

Atlas of Brain Glucose Metabolism Using Deuterium Metabolic Imaging at 3 T.

Magnetic Resonance in Medicine

A single-arm normative atlas study establishing reference values for brain glucose metabolism in healthy adults; provides methodological foundation for future research but lacks controlled comparisons and clinical validation.

MAR 3, 2026 · JOURNAL ARTICLE

Incidence of silent cerebral lesions during pulsed field ablation for paroxysmal atrial fibrillation.

Annals of Medicine

Small pilot RCT (n=62) found numerically higher but not statistically significant silent cerebral lesion rates with PFA versus RFCA, underpowered to detect differences.