Magnetic Resonance Imaging

SEP 4, 2026 · PHASE 3 TRIAL

Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial

ClinicalTrials.gov

This is an actively recruiting Phase 3 trial with no results posted; the registry record describes planned design and enrollment only, with no outcome data available for assessment.

AUG 25, 2026 · JOURNAL ARTICLE

Prefrontal-limbic circuit modulation in anxiety disorders: Differential neural effects of psychotherapy versus pharmacotherapy revealed by ALE meta-analysis.

Dialogues in Clinical Neuroscience

Meta-analysis of 27 fMRI studies with 561 patients showing differential neural mechanisms between psychotherapy and pharmacotherapy in anxiety disorders, but findings are explicitly described as exploratory due to limited and heterogeneous evidence base.

AUG 18, 2026 · JOURNAL ARTICLE

Bridging brain structures and adolescent depression and anxiety symptoms: A symptom-oriented approach.

Journal of Affective Disorders

Cross-sectional network analysis of brain structure and self-reported symptoms in adolescents, identifying associations without establishing causation, clinical outcomes, or intervention efficacy.

AUG 17, 2026 · JOURNAL ARTICLE

Domain adversarial transfer graph deep learning: A cross-site MDD fMRI data analysis framework.

Psychiatry Research. Neuroimaging

A methodological development study demonstrating a machine learning framework for depression classification using multi-site fMRI data, with validation on external data but no clinical outcome measure or direct comparison to clinical diagnosis.

AUG 5, 2026 · JOURNAL ARTICLE

Apoptosis protein markers in comorbid type 2 diabetes mellitus and depression; relationships with cognitive performance, incident dementia, and white matter hyperintensities.

Journal of Affective Disorders

A large retrospective cohort study identifying novel proteomic markers associated with dementia risk in comorbid T2DM and MDD, with clear statistical associations but requiring prospective validation and mechanistic confirmation.

AUG 3, 2026 · JOURNAL ARTICLE

Quantitative susceptibility mapping in neurodegenerative diseases: An umbrella review of iron-related biomarkers and mechanisms.

Magnetic Resonance Imaging

An umbrella review of 15 systematic reviews and meta-analyses confirming QSM as a sensitive biomarker for iron quantification across neurodegenerative diseases, but methodological quality is low and findings require cautious interpretation.

JUL 25, 2026 · JOURNAL ARTICLE

Trajectories of sleep disturbance in older adults and their associations with clinical and pathological outcomes in AD: A longitudinal study.

Sleep Medicine

Rigorous longitudinal cohort study with 774 participants, 8-year follow-up, validated trajectory modeling, and multiple biomarker endpoints showing clear associations between sleep disturbance patterns and incident AD risk with strong effect sizes.

JUL 22, 2026 · JOURNAL ARTICLE

A comparative evaluation of multiple enlarged perivascular space segmentation tools.

Magnetic Resonance Imaging

A single-centre algorithm development study with internal validation on 35 manual tracings and external validation on 18 scans, showing moderate segmentation accuracy (Dice 0.61–0.72) but acknowledged scanner-dependent variability that limits generalisability.