Biomarkers

AUG 19, 2026 · JOURNAL ARTICLE

Heat, menstruation, and mental health in adolescence and young adulthood: Understudied in climate-health research.

Dialogues in Health

A narrative review proposing conceptual frameworks and research gaps rather than presenting empirical findings; raises questions about heat, menstruation, and mental health without reporting original data or synthesizing quantitative evidence.

AUG 18, 2026 · JOURNAL ARTICLE

Association of elevated homocysteine levels with renal pathology and function in patients with IgA nephropathy: a single-center retrospective study.

Annals of Medicine

Single-center retrospective study with clear associations between elevated homocysteine and renal pathology in IgAN, but modest discriminative ability (AUC 0.756) and attenuation after adjustment for renal function limit clinical utility.

AUG 9, 2026 · JOURNAL ARTICLE

Recurrent myocardial infarction identified by centralized troponin review: Insights from the MINT trial.

American Heart Journal

A well-designed secondary analysis of an RCT showing that centralized troponin review identifies clinically meaningful recurrent MI with prognostic significance, but limited by single-trial population and surrogate endpoint focus.

AUG 5, 2026 · JOURNAL ARTICLE

Eligibility for Anti-Amyloid Therapies in Patients With Biomarker-Confirmed Atypical Alzheimer Disease Phenotypes.

Neurology

Retrospective eligibility analysis demonstrating that 70–85% of biomarker-confirmed atypical AD patients would be ineligible for anti-amyloid therapies, primarily due to cognitive thresholds misaligned with disease severity.

AUG 5, 2026 · JOURNAL ARTICLE

Apoptosis protein markers in comorbid type 2 diabetes mellitus and depression; relationships with cognitive performance, incident dementia, and white matter hyperintensities.

Journal of Affective Disorders

A large retrospective cohort study identifying novel proteomic markers associated with dementia risk in comorbid T2DM and MDD, with clear statistical associations but requiring prospective validation and mechanistic confirmation.

AUG 1, 2026 · JOURNAL ARTICLE

Impact of estimated total blood volume on NT-proBNP response to angiotensin receptor-neprilysin inhibition in acute heart failure: Insights from the PREMIER study.

American Heart Journal

Post hoc exploratory subanalysis of a parent RCT using a calculated variable (estimated total blood volume) to interrogate heterogeneity in a biomarker endpoint; the authors explicitly state findings are hypothesis-generating and require external validation.

JUL 30, 2026 · JOURNAL ARTICLE

Genetic architecture of Alzheimer's disease-related plasma biomarkers.

Neurobiology of Aging

Twin study establishing heritability and genetic correlations among Alzheimer's plasma biomarkers in a cognitively normal cohort, providing mechanistic insight but using surrogate biomarkers rather than clinical outcomes.

JUL 30, 2026 · JOURNAL ARTICLE

Exercise-based rehabilitation with or without blood flow restriction in individuals with heart failure: Protocol for the rehab-washout HF trial.

Jsams Plus

Protocol for a planned randomized trial with modest sample size (n=52) and a surrogate primary endpoint (NT-proBNP); no results yet reported.