Following this puts new work involving it at the top of your briefing, with a note saying why it is there. Links are taken from the source record, never inferred.
Small cross-sectional observational study with a single biomarker endpoint and unexpected directional finding (vigorous activity associated with higher cortisol) that requires mechanistic clarification and replication before clinical interpretation.
Two large nationally representative cohorts with consistent associations between a novel composite index and sarcopenia, but findings are observational and cross-sectional, relying on surrogate endpoints without intervention or hard clinical outcomes.
Small cross-sectional study of biomarker associations in a specific population with exploratory statistical methods; type- and timing-specific findings lack statistical significance for primary endpoints, limiting inference to hypothesis-generating.
A peer-reviewed narrative review synthesizing mechanistic evidence and therapeutic literature to propose a framework for biomarker-guided stratification in osteoarthritis, without reporting original experimental or clinical trial data.
A narrative review proposing conceptual frameworks and research gaps rather than presenting empirical findings; raises questions about heat, menstruation, and mental health without reporting original data or synthesizing quantitative evidence.
Single-center retrospective study with clear associations between elevated homocysteine and renal pathology in IgAN, but modest discriminative ability (AUC 0.756) and attenuation after adjustment for renal function limit clinical utility.
A well-designed secondary analysis of an RCT showing that centralized troponin review identifies clinically meaningful recurrent MI with prognostic significance, but limited by single-trial population and surrogate endpoint focus.
Retrospective eligibility analysis demonstrating that 70–85% of biomarker-confirmed atypical AD patients would be ineligible for anti-amyloid therapies, primarily due to cognitive thresholds misaligned with disease severity.