Major Depressive Disorder

SEP 9, 2026 · INTERVENTIONAL STUDY

Accelerated Versus Standard Intermittent Theta Burst Stimulation for Major Depressive Disorder

ClinicalTrials.gov

This is a clinical trial registry record describing a planned randomized controlled trial with no results posted; the study is actively recruiting and has not yet reported outcomes.

SEP 8, 2026 · OBSERVATIONAL STUDY

Reward Processing and Depressive Subtypes: Identifying Neural Biotypes

ClinicalTrials.gov

Observational cross-sectional neuroimaging study with no results posted; designed to identify neural biomarkers in depression but recruitment completion alone does not constitute evidence of efficacy or clinical utility.

SEP 8, 2026 · PHASE 3 TRIAL

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)

ClinicalTrials.gov

This is a trial registration with no results posted; the study is currently recruiting and has not yet reported efficacy or safety data.

AUG 21, 2026 · JOURNAL ARTICLE

From gut to brain: data-driven evidence suggests causal contribution of gut-microbiota to major depressive disorder in humans.

Gut Microbes

A large, well-characterized observational cohort with rigorous causal inference methods identifies specific taxa associated with MDD, but causal claims rest on computational inference from cross-sectional data rather than experimental validation.

AUG 21, 2026 · JOURNAL ARTICLE

Effects of H-coil TMS on suicidality in major depression: A secondary analysis of data from a multisite randomized trial comparing accelerated to once-a-day stimulation.

Journal of Affective Disorders

Secondary analysis of an FDA-regulated trial showing meaningful reductions in suicidal ideation with both TMS protocols, with accelerated dosing achieving faster onset, but limited by exploratory design and lack of a non-TMS control.

AUG 21, 2026 · JOURNAL ARTICLE

Novelty seeking and rapid symptom improvement across active and sham accelerated iTBS conditions: A pooled individual-patient data analysis.

Journal of Affective Disorders

Exploratory post-hoc analysis of pooled data from two small RCTs examining a personality trait association that failed multiplicity correction and showed no active-versus-sham difference, requiring independent replication before clinical utility.

AUG 20, 2026 · INTERVENTIONAL STUDY

Home-Based Wearable rTMS Therapy for Moderate to Severe Depression

ClinicalTrials.gov

This is a trial registration with no results posted; the study is not yet recruiting and represents planned work to test a novel wearable rTMS device.

AUG 19, 2026 · PHASE 2 TRIAL

A Study to Evaluate BMS-986511 in Adults With Major Depressive Disorder

ClinicalTrials.gov

This is a Phase 2 trial registration with no reported results; the study is not yet recruiting and represents early-stage evaluation of a novel agent.