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Standard Intermittent Theta Burst Stimulation / Major Depressive Disorder / Accelerated Intermittent Theta Burst Stimulation · Interventional Study
ClinicalTrials.gov · September 9, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a planned randomized, rater-blinded trial comparing accelerated versus standard intermittent theta burst stimulation (iTBS) for major depressive disorder, currently recruiting. No efficacy or safety results are available in this registry record; the study is in active enrollment and has not yet reported outcomes.
Interventional, Randomized, Parallel, Single masking, Treatment purpose. Major Depressive Disorder; age from 18 Years; to 65 Years. Intervention: Accelerated iTBS. Compared with: Standard iTBS — Active Comparator. n = 80. 1 site: Vietnam.
This is a planned randomized, rater-blinded trial comparing accelerated versus standard intermittent theta burst stimulation (iTBS) for major depressive disorder, currently recruiting. No efficacy or safety results are available in this registry record; the study is in active enrollment and has not yet reported outcomes.
Registry record contains no efficacy, safety, or tolerability results; study is actively recruiting.
This trial will provide evidence on whether accelerated iTBS—delivered over 15 days rather than 4 weeks—offers superior efficacy, safety, or tolerability for MDD. Results may inform treatment scheduling decisions in clinical practice, but cannot be evaluated until the study reports outcomes.
This is a clinical trial registry record describing a planned randomized controlled trial with no results posted; the study is actively recruiting and has not yet reported outcomes.
As stated by the source record.
Quoted from the source exactly as published.
This trial will provide evidence on whether accelerated iTBS—delivered over 15 days rather than 4 weeks—offers superior efficacy, safety, or tolerability for MDD. Results may inform treatment scheduling decisions in clinical practice, but cannot be evaluated until the study reports outcomes.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT07768397). This is a study registration, not published results. Lead sponsor: Military Hospital 175. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 80 participants (ESTIMATED). Conditions: Major Depressive Disorder. Interventions: DEVICE: Accelerated Intermittent Theta Burst Stimulation; DEVICE: Standard Intermittent Theta Burst Stimulation. Primary outcome measures: Change in 17-Item Hamilton Depression Rating Scale (HAM-D17) Score From Baseline to End of Treatment , Baseline (T0) and 24-72 hours after the final treatment session (T4). Brief summary: This randomized, rater-blinded clinical trial aims to compare the effectiveness, safety, and tolerability of accelerated intermittent theta burst stimulation (iTBS) with standard iTBS in adults with major depressive disorder (MDD). Participants will be randomly assigned in a 1:1 ratio to receive either accelerated or standard iTBS targeting the left dorsolateral prefrontal cortex. Participants may be psychotropic-medication naïve or may continue stable psychotropic medication according to the protocol-defined medication stability criteria. The accelerated iTBS group will receive 45 treatment sessions over approximately 15 treatment days, while the standard iTBS group will receive 20 treatment sessions over 4 weeks. The primary objective is to compare changes in depressive symptom severity, measured using the 17-item Hamilton Depression Rating Scale (HAM-D17), from baseline to the end-of-treatment assessment. Secondary and exploratory assessments include treatment response and remission, sleep quality, quality of life, cognitive measures, safety and tolerability, resting electroencephalography (EEG), and transcranial magnetic stimulation combined with EEG (TMS-EEG).
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.