Treatment Resistant Depression

SEP 9, 2026 · PHASE 2/3 TRIAL

Neural and Antidepressant Effects of Propofol

ClinicalTrials.gov

A small Phase 2/3 trial in treatment-resistant depression with completed enrollment but no posted results; the registry record alone cannot support any claim about efficacy or safety.

SEP 3, 2026 · PHASE 2/3 TRIAL

Behavioural Activation Therapy and Ketamine for Treatment-Resistant Depression

ClinicalTrials.gov

This is a Phase 2/3 trial registration with no posted results; it describes a planned intervention combining ketamine and behavioral activation for treatment-resistant depression but carries no efficacy or safety data.

AUG 21, 2026 · JOURNAL ARTICLE

Novelty seeking and rapid symptom improvement across active and sham accelerated iTBS conditions: A pooled individual-patient data analysis.

Journal of Affective Disorders

Exploratory post-hoc analysis of pooled data from two small RCTs examining a personality trait association that failed multiplicity correction and showed no active-versus-sham difference, requiring independent replication before clinical utility.

AUG 20, 2026 · INTERVENTIONAL STUDY

Dutch-Depression Outcome Trial Comparing 5 Day Multi Daily Neuronavigated Theta Burst Sessions With 6 Weeks rTMS

ClinicalTrials.gov

This is a trial registration with no results reported; the study is actively recruiting and designed to test whether an accelerated neuronavigated protocol achieves superior remission to standard rTMS in treatment-resistant depression, but outcome data are not yet available.

AUG 15, 2026 · JOURNAL ARTICLE

Comparing trajectories of cognitive functioning in treatment-resistant and non-resistant depression: a multicentre linear mixed-effects analysis.

Journal of Affective Disorders

A well-designed observational cohort study with adequate sample size and rigorous statistical method (linear mixed modelling) reporting clear differences in cognitive trajectories between TRD and non-TRD patients, but limited to 12 weeks and requiring confirmation in longer-term, interventional designs.

AUG 13, 2026 · PHASE 3 TRIAL

InTRavenous kEtAmine and immerSive virtUal Reality to Treat dEpression

ClinicalTrials.gov

This is a Phase 3 pilot feasibility study with no results yet reported; it is designed to test recruitment and retention, not to establish efficacy, and enrollment is small and still recruiting.

AUG 12, 2026 · INTERVENTIONAL STUDY

Deep Brain Stimulation for Treatment Resistant Depression With the Medtronic Activa PC+S

ClinicalTrials.gov

This is an active, uncontrolled single-arm device feasibility study with 10 enrolled participants designed to characterize neural mechanisms rather than establish efficacy; no results are reported in this registry record.

AUG 10, 2026 · PHASE 3 TRIAL

Efficacy, Safety, and Tolerability of COMP360 in Participants With TRD

ClinicalTrials.gov

This is a completed Phase 3 registry record with no results posted; the study is planned but outcomes are not yet reported in this source.