Following this puts new work involving it at the top of your briefing, with a note saying why it is there. Links are taken from the source record, never inferred.
This is a mechanistic study in a single animal model without human data, showing pathway elucidation rather than clinical evidence of efficacy or safety.
Retrospective analysis across multiple cohorts showing associations between intratumoral heterogeneity and immunotherapy response and recurrence, but limited by observational design, lack of prospective validation, and surrogate endpoints rather than hard clinical outcomes.