AUG 11, 2026 · JOURNAL ARTICLE
Intratumoral heterogeneity as a potential biomarker for immunotherapy response and postoperative recurrence in NSCLC
Frontiers in Immunology
Retrospective analysis across multiple cohorts showing associations between intratumoral heterogeneity and immunotherapy response and recurrence, but limited by observational design, lack of prospective validation, and surrogate endpoints rather than hard clinical outcomes.
Reported
Sample size (advanced NSCLC immun…504
Sample size (early-stage surgical…121
NGS testing panel scope (surgical…733-panel