Following this puts new work involving it at the top of your briefing, with a note saying why it is there. Links are taken from the source record, never inferred.
Systematic review of 96 observational and interventional studies showing consistent association between abdominal obesity and cognitive decline in middle-aged adults, with identified biological mechanisms, though causality is not established and intervention evidence remains limited.
A narrative systematic review synthesizing fragmented evidence across heterogeneous studies with inconsistent methodologies, diagnostic criteria, and sampling approaches; identifies research trends and gaps rather than establishing definitive epidemiological or causal estimates.
A comprehensive narrative review synthesizing evidence on geriatric mental disorder pathophysiology, management, and emerging approaches; provides clinical roadmap rather than new primary evidence.
Population-based cohort with 23-year follow-up and competing risk methodology identifies depressive symptoms as associated with dementia mortality, but uses death-certificate-coded outcomes rather than clinically confirmed dementia diagnoses, limiting causal inference.
Large, well-designed longitudinal cohort study with up to 18 years of follow-up, prespecified statistical correction, and consistent associations across cognitive and neuroimaging endpoints, though observational design and potential confounding limit practice-changing claims.
This is a consensus statement from multidisciplinary expert work groups convened by the American Heart Association to address clinical management gaps; it provides recommendations for practice but does not present original trial data or evidence synthesis.
An expert narrative review synthesizing clinical implications of anti-amyloid therapy for patients with concurrent cerebrovascular disease, identifying safety gaps and practice considerations rather than reporting new trial data.
Rigorous population-based retrospective analysis using Global Burden of Disease data with sophisticated temporal trend analysis and projections, providing clear epidemiological comparisons across two major countries, though descriptive rather than causal or interventional.