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A narrative systematic review synthesizing fragmented evidence across heterogeneous studies with inconsistent methodologies, diagnostic criteria, and sampling approaches; identifies research trends and gaps rather than establishing definitive epidemiological or causal estimates.
Population-based cohort with 23-year follow-up and competing risk methodology identifies depressive symptoms as associated with dementia mortality, but uses death-certificate-coded outcomes rather than clinically confirmed dementia diagnoses, limiting causal inference.
A narrative review synthesizing epidemiological, diagnostic, and therapeutic literature on a rare genetic disorder, presenting clinical consensus and recommendations rather than primary evidence from a trial or analysis.
This is a consensus statement from multidisciplinary expert work groups convened by the American Heart Association to address clinical management gaps; it provides recommendations for practice but does not present original trial data or evidence synthesis.
An expert narrative review synthesizing clinical implications of anti-amyloid therapy for patients with concurrent cerebrovascular disease, identifying safety gaps and practice considerations rather than reporting new trial data.
Retrospective cohort study of modest size with exploratory biomarker associations in a rare subgroup; joint-model findings acknowledged by authors as hypothesis-generating and requiring caution.
This is a comprehensive narrative review synthesizing current knowledge of AD genetics, pathways, and therapeutic targets rather than presenting original research evidence or clinical trial data.
South Florida Journal of Environmental and Animal Science
A narrative review synthesizing existing knowledge about TTR biology and disease mechanisms without new empirical data, animal studies, or clinical trials to support causal claims.