Immunotherapy

SEP 2, 2026 · JOURNAL ARTICLE

A phase II multi-institutional single arm trial evaluating TG4010 vaccine plus nivolumab in non-small cell lung cancer.

Oncoimmunology

Early-phase single-arm trial terminated early due to slow accrual with only 13 enrolled patients, showing limited clinical benefit (8.3% response rate) but providing mechanistic insights into immune response that warrant further investigation.

AUG 28, 2026 · JOURNAL ARTICLE

Store-operated calcium signaling modulators improve a dendritic cell-based vaccine against melanoma.

Oncoimmunology

Mechanistic study identifying a druggable pathway in dendritic cells using small molecules; lacks clinical efficacy data, human trials, or direct therapeutic outcome measurement.

AUG 24, 2026 · JOURNAL ARTICLE

Body mass index and dyslipidemia influence responses to anti-PD-1 immunotherapy in colorectal cancer.

Annals of Medicine

A retrospective single-centre cohort study identifies BMI and dyslipidemia as associations with improved PFS in anti-PD-1-treated CRC, supported by exploratory lipidomic profiling, but lacks a control arm and prospective design to establish causation or clinical utility.

AUG 20, 2026 · JOURNAL ARTICLE

Immune dysregulation in osteoarthritis: Mechanisms, biomarkers, and therapeutic opportunities.

Journal of Translational Autoimmunity

A peer-reviewed narrative review synthesizing mechanistic evidence and therapeutic literature to propose a framework for biomarker-guided stratification in osteoarthritis, without reporting original experimental or clinical trial data.

AUG 17, 2026 · JOURNAL ARTICLE

The current role of immunotherapy in treating nasopharyngeal carcinoma.

Human Vaccines & Immunotherapeutics

This is a comprehensive narrative review synthesizing evidence on immunotherapy's current role in nasopharyngeal carcinoma management, drawing on completed and ongoing clinical trials to inform clinical practice and research priorities.

JUL 29, 2026 · JOURNAL ARTICLE

Protocol for a cohort study: evaluating the effect of neoadjuvant immunochemotherapy on intraoperative remifentanil consumption during IoC2-guided anesthesia in elderly patients with esophageal cancer.

Annals of Medicine

This is a protocol for a prospective observational cohort study not yet conducted; it describes planned methods and outcomes without results, establishing hypothesis-generating potential but lacking empirical evidence.

JUL 28, 2026 · JOURNAL ARTICLE

The evolution of cellular therapies in sarcoma: Breakthroughs, challenges, and future directions.

Human Vaccines & Immunotherapeutics

A narrative review summarizing the landscape of cellular therapies in sarcoma, reporting one FDA approval and describing early-stage investigational approaches without comparative efficacy data or quantified outcomes.

JUL 26, 2026 · JOURNAL ARTICLE

Characterization of persistent HPV-specific activated T cells in head and neck squamous cell carcinoma.

Oncoimmunology

Single-center mechanistic study with small sample size (n=4 for single-cell analysis) characterizing HPV-specific T-cell populations; functional validation of TCRs supports hypothesis but lacks clinical endpoint data or comparative outcome analysis.