Following this puts new work involving it at the top of your briefing, with a note saying why it is there. Links are taken from the source record, never inferred.
Single-centre prospective observational study with no control group measuring thyroid hormone changes during childhood cancer treatment; descriptive findings on prevalence without comparative analysis or hard clinical outcomes.
Rigorous nationwide population-based cohort study with large sample, long follow-up, and multivariable adjustment demonstrates clear associations between thyroidectomy/thyroid hormone therapy and multiple metabolic outcomes; not practice-changing because it establishes risk rather than testing an intervention to mitigate it.
A single-centre retrospective study with modest sample size identifying predictive biomarkers for radioiodine response using immunohistochemistry and mutation analysis; results are encouraging but require validation in an independent cohort before clinical adoption.
This is a narrative review synthesizing experimental animal studies and emerging translational work on 3,5-T2; it raises mechanistic questions and identifies knowledge gaps rather than reporting a definitive clinical result or trial outcome.
A narrative review synthesizing mechanistic, epidemiological, and therapeutic evidence to recommend integration of liver assessment into cardiovascular-kidney-metabolic risk stratification and therapy selection in clinical practice.
Single-centre retrospective cohort study with clinical endpoints (PFS, OS) in a defined population, showing statistically significant associations, but limited by retrospective design, lack of mechanistic validation, and absence of external validation.
Population-based cluster analysis identifying three gout phenotypes, but no intervention comparison, no control group, and outcomes are observational descriptors of care patterns rather than clinical trial endpoints.
A comprehensive narrative review synthesizing current understanding of pediatric hyperuricemia genetics, mechanisms, and clinical management, intended to inform clinical practice and identify evidence gaps rather than report original research findings.