AUG 10, 2026 · JOURNAL ARTICLE
Dynamic phenotyping of radioiodine-refractory differentiated thyroid cancer: thyroglobulin trajectories, dual-modal imaging, and genotype-defined treatment resistance
Frontiers in Endocrinology
Retrospective integration of longitudinal biomarkers, dual-modal imaging, and genomics in a single-centre cohort identifies genotype-phenotype associations in RAIR-DTC, but lacks prospective validation or a randomized comparator to establish clinical utility.
Reported
Median sTg at initial radioiodine…18.7 ng/mL
Median sTg at RAIR-DTC diagnosis302.7 ng/mL
Area under the curve for pre-radi…0.911