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A retrospective before-after cohort study with historical controls showing clinically meaningful improvements in anxiety, depression, adherence, and social outcomes in adolescents with thyroid cancer, but requiring prospective RCT confirmation to establish causality.
Single-center machine learning model with reasonable test-set performance (AUC 0.894) and independent temporal validation, but surrogate endpoints (biochemical markers and imaging classification) rather than hard clinical outcomes, and no comparison to standard risk stratification.
A narrative review synthesizing mechanistic and exploratory literature on microbiome-immune interactions in thyroid cancer, raising questions about therapeutic targets rather than testing defined hypotheses with clinical outcomes.
A narrative review synthesizing mechanistic understanding and clinical evidence on TERT mutations in thyroid cancer, with expert consensus on risk stratification and emerging therapeutic strategies, but not a primary data study.
Single-centre prospective observational study with no control group measuring thyroid hormone changes during childhood cancer treatment; descriptive findings on prevalence without comparative analysis or hard clinical outcomes.
Rigorous nationwide population-based cohort study with large sample, long follow-up, and multivariable adjustment demonstrates clear associations between thyroidectomy/thyroid hormone therapy and multiple metabolic outcomes; not practice-changing because it establishes risk rather than testing an intervention to mitigate it.
A single-centre retrospective study with modest sample size identifying predictive biomarkers for radioiodine response using immunohistochemistry and mutation analysis; results are encouraging but require validation in an independent cohort before clinical adoption.
This is a narrative review synthesizing experimental animal studies and emerging translational work on 3,5-T2; it raises mechanistic questions and identifies knowledge gaps rather than reporting a definitive clinical result or trial outcome.