Researcher

Yue Zhang

Anyang Hospital of Traditional Chinese Medicine

2 developments in the corpus

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AUG 14, 2026 · JOURNAL ARTICLE

Structural basis for T-cell receptor recognition of p53 Y220D, a human cancer neoantigen

Acta Crystallographica Section D Structural Biology

A structural biology study using X-ray crystallography to elucidate atomic-level mechanisms of TCR recognition of a cancer neoantigen; mechanistic work that raises questions about TCR specificity rather than testing clinical efficacy or providing definitive evidence for therapeutic application.

Hypothesis-GeneratingJianfeng Zhao Zhihui Duan Junping Wu

Study details

DesignStructural biology study using X-ray crysta…

InterventionTCR 4414A recognition of p53 Y220D neoepito…

ComparatorWild-type p53 peptide; structural compariso…

AUG 10, 2026 · JOURNAL ARTICLE

Dynamic phenotyping of radioiodine-refractory differentiated thyroid cancer: thyroglobulin trajectories, dual-modal imaging, and genotype-defined treatment resistance

Frontiers in Endocrinology

Retrospective integration of longitudinal biomarkers, dual-modal imaging, and genomics in a single-centre cohort identifies genotype-phenotype associations in RAIR-DTC, but lacks prospective validation or a randomized comparator to establish clinical utility.

PromisingQian Gu Gongxun Tan Thyroid Cancer Diagnosis and Treatment

Reported

Median sTg at initial radioiodine…18.7 ng/mL

Median sTg at RAIR-DTC diagnosis302.7 ng/mL

Area under the curve for pre-radi…0.911