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Junping Wu

University of South China

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AUG 14, 2026 · JOURNAL ARTICLE

Structural basis for T-cell receptor recognition of p53 Y220D, a human cancer neoantigen

Acta Crystallographica Section D Structural Biology

A structural biology study using X-ray crystallography to elucidate atomic-level mechanisms of TCR recognition of a cancer neoantigen; mechanistic work that raises questions about TCR specificity rather than testing clinical efficacy or providing definitive evidence for therapeutic application.

Hypothesis-GeneratingJianfeng Zhao Zhihui Duan Junping Wu

Study details

DesignStructural biology study using X-ray crysta…

InterventionTCR 4414A recognition of p53 Y220D neoepito…

ComparatorWild-type p53 peptide; structural compariso…

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