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A well-designed cross-sectional study with biomarker-confirmed early AD and matched controls, demonstrating a mechanistic link between motor cortical hyperexcitability and cognitive impairment, but limited by cross-sectional design and lack of longitudinal or clinical outcome validation.
Twin study establishing heritability and genetic correlations among Alzheimer's plasma biomarkers in a cognitively normal cohort, providing mechanistic insight but using surrogate biomarkers rather than clinical outcomes.
Mouse model identifies mTORC2-Nav1.2 mechanism underlying hyperexcitability in Alzheimer's disease, but lacks clinical translation or quantified intervention effect.
In vitro mechanistic study demonstrating Aβ1-42 effects on glial and vascular cells; lacks in vivo validation and clinical outcome data, limiting immediate translational impact.
A single-centre prospective cohort study with well-defined neuropsychological criteria identifying a discrete clinical phenotype (decreased awareness of cognitive decline) associated with multimodal AD biomarkers in cognitively unimpaired individuals; promising but requires replication and validation in independent populations.
Cross-sectional content analysis of social media videos with no comparative arm, reporting correlational findings on information quality without effect sizes or statistical tests; useful for identifying a public health problem but insufficient to guide clinical practice.
Observational network analysis identifying associations between blood inflammation markers and aging/AD biomarkers, but without causal inference, comparator group, or effect sizes to support clinical decision-making.