Following this puts new work involving it at the top of your briefing, with a note saying why it is there. Links are taken from the source record, never inferred.
This is a mechanistic review proposing a novel conceptual framework linking PAH chronotoxicity to cancer via circadian dysregulation; it raises questions rather than testing them empirically.
This is a narrative review synthesizing mechanistic concepts and therapeutic rationales without reporting primary empirical findings, clinical trial data, or comparative evidence from original research.
A narrative review of mechanistic pathways linking protein lactylation to cancer phenotypes; raises questions about therapeutic potential but reports no empirical data, effect sizes, or clinical outcomes.
Mechanistic proof-of-concept in cell lines using CRISPR-dCas9 epigenetic editing, without in vivo validation or clinical outcomes, raising a therapeutic hypothesis rather than establishing efficacy.
This is a narrative review synthesizing mechanistic observations about SHMT2 in cancer; it raises questions about therapeutic potential rather than testing an intervention or reporting new empirical evidence.
This is a narrative review that synthesizes existing knowledge about cellular senescence mechanisms in liver disease; it raises questions about therapeutic targeting rather than reporting original empirical results or clinical outcomes.
In vitro mechanistic study in cancer cell lines demonstrating that DNMT1 inhibition modulates EMT markers and reduces invasiveness in docetaxel-resistant prostate cancer, but lacks in vivo validation, clinical endpoints, or human data.
Systematic review of 20 studies confirming that tissue-based DNA methylation is frequently associated with worse survival in NSCLC, but methodological heterogeneity and lack of meta-analysis prevent definitive clinical recommendations.