Epigenetics and DNA Methylation

SEP 10, 2026 · JOURNAL ARTICLE

In-vitro incubation of human sperm does not change DNA methylation

Human Reproduction Open

A small, single-centre in-vitro study with a null finding; the design is sound but the sample is limited (n=15) and the scope restricted to three media conditions, leaving open whether other culture or earlier developmental stages affect sperm DNA methylation.

SEP 10, 2026 · JOURNAL ARTICLE

The deubiquitinating enzyme regulatory network in malignant progression of breast cancer encompasses mechanisms of action, clinical significance and emerging therapeutic targets

Discover Oncology

This is a comprehensive narrative review synthesizing mechanistic and preclinical findings on deubiquitinases in breast cancer, with no clinical trial data, prospective validation, or regulatory approval to support practice change.

SEP 10, 2026 · JOURNAL ARTICLE

An Atlas of Specificity Protein 1 in Oral Cancer: Networks, Therapeutics, and Priorities: A Scoping Review and scRNA-seq Analysis

International Dental Journal

A scoping review synthesizing preclinical and mechanistic evidence on Sp1 in OSCC with scRNA-seq analysis, raising translational questions but reporting no clinical trials or human efficacy data.

SEP 9, 2026 · JOURNAL ARTICLE

Targeted 3.34-Million CpG Site Sequencing Reveals Preliminary Cord Blood Epigenetic Alterations of Autism Spectrum Disorder: A Pilot Study Highlighting the PCDHA1–PCDHA8 Cluster

International Journal of Molecular Sciences

Pilot study with n=2 ASD cases using exploratory epigenetic sequencing; identifies candidate loci requiring validation in larger cohorts.

SEP 9, 2026 · JOURNAL ARTICLE

Minimal-length CAG repeats in AR define a hyperactive AR–LSD1 axis driving metabolic reprogramming in prostate cancer

Proceedings of the National Academy of Sciences

Cell line study identifying a mechanistic link between AR CAG repeat polymorphism and metabolic reprogramming; lacks in vivo validation, patient outcome data, or clinical endpoint evidence.

SEP 9, 2026 · JOURNAL ARTICLE

Ribitoborate Synergism with Histone Deacetylase Inhibitor Romidepsin as a Potential Treatment for Breast Cancer

International Journal of Molecular Sciences

In vitro mechanistic study in a single TNBC cell line suggesting synergy between two agents, lacking any in vivo validation, patient data, or clinical trial evidence to support therapeutic application.

SEP 8, 2026 · JOURNAL ARTICLE

Epigenetic and Transcriptional Rewiring of Circadian Clock Genes by Polycyclic Aromatic Hydrocarbons: Implications for Lung and Breast Cancer Initiation and Progression

Innovative Medicines & Omics

This is a mechanistic review proposing a novel conceptual framework linking PAH chronotoxicity to cancer via circadian dysregulation; it raises questions rather than testing them empirically.

SEP 8, 2026 · JOURNAL ARTICLE

Epigenetic Plasticity in Triple-Negative Breast Cancer: Mechanisms of Therapy Resistance, Biomarkers, and Therapeutic Vulnerabilities

Biomedicines

This is a narrative review synthesizing mechanistic concepts and therapeutic rationales without reporting primary empirical findings, clinical trial data, or comparative evidence from original research.