Engineering Research Center of Key Technology and Industrialization of Cell-Based Vaccine, Ministry of Education, Biomedical Research Center, Northwest Minzu University, Lanzhou, China.
2 developments in the corpus
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This is a proof-of-concept chemical synthesis and mechanism study demonstrating a novel drug design strategy in cells and xenografts, lacking clinical endpoints or comparison to standard therapy.
Mouse model and in vitro mechanistic data identify AKT3-dependent pathways for EMCV-mediated blood-brain barrier disruption but lack human validation or intervention trial evidence.