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Researcher

Ruofei Feng

Engineering Research Center of Key Technology and Industrialization of Cell-Based Vaccine, Ministry of Education, Biomedical Research Center, Northwest Minzu University, Lanzhou, China.

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JUL 3, 2026

Encephalomyocarditis virus impairs the blood-brain barrier by degrading tight junction proteins via AKT3-dependent autophagic and apoptotic pathways.

Virulence

Mouse model and in vitro mechanistic data identify AKT3-dependent pathways for EMCV-mediated blood-brain barrier disruption but lack human validation or intervention trial evidence.

PreliminaryRuofei Feng Xueer Dou Na Wang

Study details

DesignPreclinical in vivo and in vitro mechanisti…

InterventionEMCV infection, AKT3 knockdown, and pharmac…

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