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Cross-sectional study with multivariable regression and mediation analysis confirms known associations and quantifies mediating pathways in a well-defined clinical population.
Meta-analysis of 3 RCTs and 8 observational studies shows apixaban and rivaroxaban associated with lower bleeding risk versus warfarin in dialysis patients with AF, but efficacy endpoints show substantial heterogeneity and RCT-only analysis lacked statistical significance; evidence is suggestive but requires dedicated large RCTs.