Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
2 developments in the corpus
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Rigorous test-negative design study with large real-world population (73,160 cases) over 15 years demonstrating vaccine effectiveness against the target pathogen with precise confidence intervals; not practice-changing because vaccination policy was already implemented.
Meta-analysis of 3 RCTs and 8 observational studies shows apixaban and rivaroxaban associated with lower bleeding risk versus warfarin in dialysis patients with AF, but efficacy endpoints show substantial heterogeneity and RCT-only analysis lacked statistical significance; evidence is suggestive but requires dedicated large RCTs.