Loading
Kidney Failure, Chronic / Kidney Transplantation · Journal article
Renal Failure · August 28, 2026
Encouraging direction, but not yet definitive.
This retrospective paired-kidney analysis from a Chinese centre identified distinct recipient-driven (higher BMI, longer dialysis duration, more HLA mismatches) and donor-driven (elevated terminal creatinine, prolonged hypertension, longer warm ischemia time) risk factors for delayed graft function. The paired design elegantly isolates these pathways, but single-centre conduct and retrospective methods limit generalisability and strength of inference.
Retrospective cohort study with paired-kidney analytical framework. Deceased-donor kidney transplant recipients at the Second Affiliated Hospital of Hainan Medical University, specifically pairs receiving kidneys from the same donor.. Intervention: Deceased-donor kidney transplantation (both kidneys from single donor allocated to two recipients). Compared with: Paired comparison: within-donor analysis isolating recipient-driven versus donor-driven determinants of delayed graft function. n = 356. Single centre: Second Affiliated Hospital of Hainan Medical University, Haikou, China.
Recipient BMI independently predicted DGF in discordant pairs (OR = 1.22 per unit, 95% CI 1.03–1.44, p = 0.019) Dialysis duration independently predicted DGF in discordant pairs (OR = 1.31 per year, 95% CI 1.01–1.69, p = 0.041) HLA mismatch number independently predicted DGF in discordant pairs (OR = 1.47, 95% CI 1.06–2.02, p = 0.019)
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
Clinicians can use these identified risk factors to anticipate DGF risk: modifiable recipient factors (BMI, dialysis duration) and non-modifiable donor factors (terminal creatinine, hypertension duration, warm ischemia time) warrant consideration in recipient selection, perioperative management, and organ allocation decisions. However, findings are from a single centre and require prospective validation before integration into clinical algorithms.
A retrospective cohort study with sound paired-kidney design isolating donor and recipient risk factors for delayed graft function, but limited by single-centre recruitment and lack of prospective validation.
As stated by the source record.
Quoted from the source exactly as published.
Clinicians can use these identified risk factors to anticipate DGF risk: modifiable recipient factors (BMI, dialysis duration) and non-modifiable donor factors (terminal creatinine, hypertension duration, warm ischemia time) warrant consideration in recipient selection, perioperative management, and organ allocation decisions. However, findings are from a single centre and require prospective validation before integration into clinical algorithms.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Background. Delayed graft function (DGF) is a frequent complication of kidney transplantations. When both kidneys from a single deceased donor are transplanted into two recipients, DGF outcomes may be discordant, affecting only one recipient, or concordant, affecting both recipients. The factors underlying these within-donor differences, particularly in the Chinese population, remain poorly understood.Methods. We retrospectively analyzed 356 deceased-donor kidney transplants performed in our hospital between 2018 and 2022. We first examined recipient-specific factors associated with discordant DGF among paired recipients from the same donor. Second, we assessed donor factors associated with concordant DGF in both recipients.Results. In discordant pairs, multivariate regression identified recipient body mass index (BMI; odds ratio [OR] = 1.22, per unit changes; 95% CI 1.03-1.44; p = 0.019), dialysis duration (OR = 1.31, per years; 95% CI 1.01-1.69; p = 0.041), and number of HLA mismatches (OR = 1.47, 95% CI 1.06-2.02; p = 0.019) as independent predictors of DGF. Concordant analyses comparing donor pairs with DGF in both recipient and donor terminal creatinine (OR = 1.03, per mg/dL; 95% CI 1.01-1.05; p = 0.001), duration of donor hypertension (OR = 2.40, per years; 95% CI 1.52-3.81; p < 0.001), and donor warm ischemia time (OR = 1.67, per hours; 95% CI 1.15-2.44; p = 0.007) were independently associated with DGF in both recipients.Conclusions. Among kidney recipients from the same donor, higher BMI, longer dialysis duration, and greater HLA mismatch independently predicted DGF when outcomes were discordant. Conversely, donor-related factors, higher terminal creatinine, longer hypertension duration, and prolonged warm ischemia drove DGF in both recipients.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.