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This is a narrative review synthesizing mechanistic and clinical evidence on circadian rhythm disruption in MDD, offering conceptual synthesis and therapeutic direction without conducting systematic appraisal or reporting original trial data.
Open-label, single-arm study with small sample (n=11 at 3 months, n=6 at 6 months) and no control group; early signal warrants controlled investigation.
Review discussing a therapeutic strategy combining indomethacin with photosensitizers to enhance photodynamic therapy by targeting COX-2, without presenting primary clinical or experimental data.