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Lim Zhixin

Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

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JUN 3, 2026 · JOURNAL ARTICLE

Circadian rhythms in major depressive disorder: mechanistic insights and therapeutic frontiers.

Annals of Medicine

This is a narrative review synthesizing mechanistic and clinical evidence on circadian rhythm disruption in MDD, offering conceptual synthesis and therapeutic direction without conducting systematic appraisal or reporting original trial data.

Expert GuidanceChronotherapy Phototherapy Lim Zhixin

Reported

Global MDD prevalenceover 264 million people

Surge in MDD casesnearly 50% over the past 30 years

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