Drug or technology

Pneumococcal Vaccines

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AUG 17, 2026 · JOURNAL ARTICLE

Pneumococcal vaccination status in critically ill patients: A cross-sectional study.

Human Vaccines & Immunotherapeutics

A single-centre cross-sectional survey with self-reported vaccination status and no clinical outcomes; findings describe a gap but cannot establish causation or guide clinical practice changes.

PreliminaryPneumococcal Vaccines Maiko Motoki Influenza Vaccines

Reported

Sample size725

Pneumococcal vaccination coverage17.1%

No pneumococcal vaccination51.2%

JUL 20, 2026 · JOURNAL ARTICLE

The relative immunogenicity of 20-valent and 15-valent pneumococcal conjugate vaccines: A systematic review and network meta-analysis.

Human Vaccines & Immunotherapeutics

Network meta-analysis of 17 trials confirms differential serotype-specific immunogenicity between higher-valent pneumococcal vaccines, with PCV15 showing mostly superior responses.

Important Confirmatory EvidenceErika Alessandra Strangi Pneumococcal Vaccines Vaccines, Conjugate

Reported

Primary endpointOPA geometric mean titers at 30 days

Trials meeting inclusion17 trials

Trials contributing OPA data9 trials

JUN 29, 2026 · JOURNAL ARTICLE

Suboptimal vaccine coverage for preventable respiratory infections in children with cystic fibrosis in the Cystic Fibrosis Regional Reference Centre of Tuscany: Need for improving preventive strategies.

Human Vaccines & Immunotherapeutics

Single-center retrospective audit of vaccination coverage in a regional CF cohort; documents suboptimal uptake for influenza and COVID-19 but lacks comparative design, causal analysis, or intervention testing to support practice change.

PreliminaryPneumococcal Vaccines Influenza Vaccines Respiratory Tract Infections

Reported

Hib vaccination coverage131/133 (98.5%)

Pneumococcal primary series compl…97%

Influenza vaccination coverage (p…79.6%

JUN 19, 2026 · JOURNAL ARTICLE

Post-pandemic impact on the epidemiology of invasive pneumococcal disease: consensus statement from the Latin American Society of Pediatric Infectious Diseases (SLIPE).

Expert Review of Vaccines

Expert consensus statement synthesizing regional surveillance data and literature to guide post-pandemic pneumococcal vaccination policy in Latin America, but without new primary data or quantified efficacy evidence.

Expert GuidanceCarlos Torres Pneumococcal Vaccines Angela Gentile

JUN 3, 2026 · JOURNAL ARTICLE

Targeted pneumococcal conjugate vaccination strategies for high-risk children.

Human Vaccines & Immunotherapeutics

This mini-review synthesizes evidence on disease burden and immune vulnerability in high-risk child populations to inform targeted PCV strategies, but contains no new primary data or comparative trials.

Expert GuidanceKim Mulholland Zheng Quan Toh Pneumococcal Vaccines

Reported

Pneumococcal contribution to chil…28% of approximately 500,000 deaths

Mortality risk ratio: moderately…2

Mortality risk ratio: severely un…5