Bipolar Disorder

SEP 10, 2026 · OBSERVATIONAL STUDY

Evaluation of the Genetics of Bipolar Disorder

ClinicalTrials.gov

This is a completed observational genetics registry study with no reported results in this record; it describes enrollment and planned outcome measures only, making it preliminary evidence pending publication of findings.

AUG 24, 2026 · JOURNAL ARTICLE

Hair as a window to mood disorders: Discrimination of bipolar affective disorder using mapping spectroscopy.

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy

This is a proof-of-concept spectroscopic study with no sample size reported, no clinical validation, no comparator performance data, and no independent replication—it raises mechanistic and diagnostic questions rather than answering them.

AUG 19, 2026 · INTERVENTIONAL STUDY

COMpassion for Psychiatric Disorders And Self-Stigma

ClinicalTrials.gov

This is a clinical trial registry record with no reported results; the study is actively recruiting and designed to evaluate a behavioral intervention for self-stigma across five psychiatric conditions.

AUG 18, 2026 · JOURNAL ARTICLE

The impact of the motherhood role on recovery motivation in women with severe mental illness.

Annals of Medicine

Cross-sectional observational study with modest sample size (n=115) examining associations between maternal role perception and recovery motivation in women with severe mental illness; correlational findings require replication and do not establish causation or clinical utility.

AUG 13, 2026 · OBSERVATIONAL STUDY

NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder

ClinicalTrials.gov

This is a prospective natural history study registration with no results reported; it describes planned enrollment and measurement methods for understanding relationships among physical activity, sleep, and mood disorders.

AUG 11, 2026 · JOURNAL ARTICLE

Quality-of-life and self-perceived inequity in people with severe mental illness: the SOFIA pilot study.

Scandinavian Journal of Primary Health Care

A pilot cluster-RCT with modest sample size and short follow-up showing selective improvements in self-perceived inequity (two domains) but no effect on primary needs-based QoL or health-related QoL; results are real but limited and the authors call for larger trials.

AUG 10, 2026 · JOURNAL ARTICLE

Intravenous Ketamine reduces psychological pain in suicidal inpatients: A secondary analysis of a six-week randomized placebo-controlled trial.

Journal of Affective Disorders

A double-blind RCT with adequate sample size and pre-specified primary endpoint shows ketamine reduces psychological pain acutely in suicidal inpatients, but effects do not persist beyond 96 hours and the clinical significance of this surrogate outcome remains unclear.

AUG 10, 2026 · JOURNAL ARTICLE

Prevalence and outcomes of real-world bipolar depression patients underrepresented in guideline RCTs.

Journal of Affective Disorders

Cross-sectional observational study of a single outpatient cohort using a surrogate measure (patient-perceived improvement) with no randomization or control group, raising questions about real-world treatment outcomes but not providing confirmatory evidence.