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Christophe Demattei

Department of Biostatistics, Epidemiology, Public Health and Innovation in Methodology, CHU Nîmes, Nîmes, France.

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AUG 10, 2026 · JOURNAL ARTICLE

Intravenous Ketamine reduces psychological pain in suicidal inpatients: A secondary analysis of a six-week randomized placebo-controlled trial.

Journal of Affective Disorders

A double-blind RCT with adequate sample size and pre-specified primary endpoint shows ketamine reduces psychological pain acutely in suicidal inpatients, but effects do not persist beyond 96 hours and the clinical significance of this surrogate outcome remains unclear.

PromisingChristophe Demattei Bipolar Disorder Fabrice Jollant

Reported

Sample size: ketamine arm73

Sample size: placebo arm83

Ketamine dose0.5 mg/kg

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