Drug or technology

Nanoparticles

7 developments in the corpus

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AUG 12, 2026 · JOURNAL ARTICLE

Targeted delivery of mRNA to immune cells for in vivo cell therapy.

Drug Delivery

A comprehensive review article synthesizing current knowledge on mRNA delivery engineering strategies to immune cells, identifying translational barriers and technical advances rather than reporting original experimental results or clinical outcomes.

Expert GuidanceNanoparticles Jinfeng Deng Yumin Li

Reported

Ex vivo CAR-T manufacturing durat…typically 3–4 weeks

AUG 4, 2026 · JOURNAL ARTICLE

A brain-targeted biomimetic iron-porphyrin covalent organic framework nanoplatform for Alzheimer's disease: synergistic intervention via antioxidant, Aβ-regulating and immunomodulatory effects.

Journal of Colloid and Interface Science

Preclinical in vitro and transgenic mouse study of a novel nanoplatform without human data, efficacy metrics, or comparison to standard-of-care controls; demonstrates proof-of-concept but requires clinical translation.

PreliminaryNanoparticles Alzheimer Disease Fengmei Yang

Reported

Copper-ion chelation rate41.78%

JUL 7, 2026 · JOURNAL ARTICLE

Lymph node-targeted mRNA delivery of fine-tuned peptide-nanocomplexes for SARS-CoV-2 Vaccination.

Biomaterials

Preclinical mouse study demonstrates a novel peptide-nanocomplex delivery system with improved lymph node targeting and prolonged antigen expression compared to lipid nanoparticles, with comparable neutralizing antibody responses and superior CD8+ T cell responses, but lacks human data and clinical validation.

PromisingNanoparticles Dong Woo Lee Hayoon Jeong

Reported

Particle sizeunder 200 nm

Duration of mRNA expression (pept…up to 7 days

Duration of mRNA expression (LNPs)within 48 h

JUL 6, 2026 · REVIEW/PERSPECTIVE

Next-generation vaccine adjuvants: Integrating nanotechnology, systems immunology, and computational approaches for precision vaccinology.

Human Vaccines & Immunotherapeutics

A translational framework review synthesizing adjuvant mechanisms and design strategies without reporting original comparative data.

Expert GuidanceNanoparticles Setareh Haghighat Vaccine Development

JUN 27, 2026 · JOURNAL ARTICLE

Mapping the analytical toolbox for next-generation adjuvant immunology: A bibliometric analysis of characterization techniques and emerging trends (2006-2025).

Talanta

A bibliometric analysis mapping research trends and technique landscapes; describes the field rather than testing a clinical hypothesis or intervention outcome.

Hypothesis-GeneratingNanoparticles Vaccine Development Wanpei Liang

Reported

Sample size8637

Study period2006-2025

JUN 16, 2026 · JOURNAL ARTICLE

Preventive and therapeutic efficacy of mRNA/LNP vaccines encoding HPV16 E6 and E7 in an early-intervention HPV tumor mouse models.

Human Vaccines & Immunotherapeutics

Preclinical murine tumor model study demonstrating HPV16 E7 mRNA/LNP vaccine efficacy in early-intervention setting, with no human data or comparator arm against standard therapy.

PreliminaryNanoparticles Kittipan Tharakhet Chutitorn Ketloy

Reported

Tumor inoculum size5,000–10,000 TC-1 cells

E7 dose (low, single intramuscula…1 µg

Therapeutic E7 dose (single or fi…10 µg

JUN 11, 2026 · JOURNAL ARTICLE

Nanomaterial-based vaccines: An advanced approach against rotavirus: A review article.

Human Vaccines & Immunotherapeutics

This is a narrative review proposing nanomaterial-based vaccines as a solution to rotavirus vaccine efficacy gaps in LMICs, without presenting original experimental data or clinical trial results.

Hypothesis-GeneratingNanoparticles Ali Teimoori Kurosh Kalantar

Reported

Vaccine effectiveness in high-inc…80–90%

Vaccine effectiveness in low- and…40–70%