JUN 16, 2026 · JOURNAL ARTICLE
Preventive and therapeutic efficacy of mRNA/LNP vaccines encoding HPV16 E6 and E7 in an early-intervention HPV tumor mouse models.
Human Vaccines & Immunotherapeutics
Preclinical murine tumor model study demonstrating HPV16 E7 mRNA/LNP vaccine efficacy in early-intervention setting, with no human data or comparator arm against standard therapy.
Reported
Tumor inoculum size5,000–10,000 TC-1 cells
E7 dose (low, single intramuscula…1 µg
Therapeutic E7 dose (single or fi…10 µg