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Dong Woo Lee

Department of Dental Regenerative Biotechnology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, 03080, Republic of Korea; Research Institute, Nano Intelligent Biomedical Engineering Corporation (NIBEC),

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JUL 7, 2026 · JOURNAL ARTICLE

Lymph node-targeted mRNA delivery of fine-tuned peptide-nanocomplexes for SARS-CoV-2 Vaccination.

Biomaterials

Preclinical mouse study demonstrates a novel peptide-nanocomplex delivery system with improved lymph node targeting and prolonged antigen expression compared to lipid nanoparticles, with comparable neutralizing antibody responses and superior CD8+ T cell responses, but lacks human data and clinical validation.

PromisingNanoparticles Dong Woo Lee Hayoon Jeong

Reported

Particle sizeunder 200 nm

Duration of mRNA expression (pept…up to 7 days

Duration of mRNA expression (LNPs)within 48 h

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