Precision medicine selects individual treatments from a small toolbox of therapies already available. Personalized drug discovery (PDD) brings this concept one step ahead, developi
Preclinical mechanistic study in an animal model with no clinical trial data, demonstrating target engagement and a potential therapeutic approach requiring confirmation in human subjects.
This is a narrative review of mechanistic approaches and recent advances in a drug development strategy, without empirical trial data, clinical outcomes, or efficacy comparisons to support a clinical claim.