iScience

OCT 23, 2026 · JOURNAL ARTICLE

A single arm phase II trial of chidamide plus cisplatin in advanced adenoid cystic carcinoma

iScience

Systemic therapy for recurrent or metastatic adenoid cystic carcinoma remains limited, and durable disease control is difficult to achieve. We conducted a prospective, single-arm p

OCT 14, 2026 · JOURNAL ARTICLE

Circadian misalignment associates with inflammation, gut barrier, and microbiome composition in humans with obesity

iScience

Circadian disruption has been linked to metabolic syndrome, but the biological links between circadian phenotypes and metabolic inflammation in humans remain incompletely character

OCT 13, 2026 · JOURNAL ARTICLE

Acarbose differentially affects gut microbial metabolism of maltose and sucrose, distinctly modulating host metabolism

iScience

Gut microbiota act as beneficial symbionts of the hosts. Administration of α-glucosidase inhibitors (α-GIs) is considered to promote the microbiota's carbohydrate availability, mod

OCT 13, 2026 · JOURNAL ARTICLE

Quantitative systems pharmacology modeling of class I–III BRAF-mutant NSCLC enables subgroup treatment analysis and combination therapy design

iScience

BRAF-mutant non-small cell lung cancer (NSCLC) comprises three functional classes (I–III) with distinct driving mechanisms, yet effective therapies for classes II and III remain li

OCT 5, 2026 · JOURNAL ARTICLE

Caloric restriction attenuates NLRP3 inflammasome activation and oxidative stress in leukocytes of patients with obesity

iScience

Obesity promotes chronic low-grade inflammation through metabolic stress and activation of the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome. The effects

OCT 1, 2026 · JOURNAL ARTICLE

Bidirectional metabolic-vascular feedback loops in heart failure: From myocardial energetics to multisystem cardiometabolic crosstalk

iScience

Heart failure (HF) is a multisystem syndrome in which myocardial dysfunction is shaped by metabolic, vascular, and extracardiac abnormalities. Across HFrEF and HFpEF, impaired subs

SEP 30, 2026 · JOURNAL ARTICLE

Divergent ectopic fat distribution and adipokine/hepatokine levels characterize the metabolically healthy overweight/obesity phenotype

iScience

The metabolically healthy overweight/obesity (MHOO) phenotype combines excess adiposity with preserved cardiometabolic health. We compared specific fat depots, circulating adipokin

SEP 18, 2026 · JOURNAL ARTICLE

Niche-specific immune and microbial signatures across the healthy upper respiratory tract mucosa

iScience

Host-microbe interactions in the upper respiratory tract (URT) niches that form the first line of defense against respiratory infections are incompletely understood. We profiled im