Loading
Life sciences · Journal article
iScience · October 14, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Journal article.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
This record has not been graded across any dimension yet. Treat the label above as provisional and read the source.
What is missing. This record has no bottom line, key findings, reported figures, evidence dimensions. That is a gap in the analysis, not a judgement about the study.
Circadian disruption has been linked to metabolic syndrome, but the biological links between circadian phenotypes and metabolic inflammation in humans remain incompletely characterized. We analyzed 87 adults with obesity from a randomized clinical trial to examine whether gut microbiome features and intestinal permeability relate to circadian misalignment and metabolic inflammation. Circadian phenotype was assessed using chronotype and meal timing, metabolic inflammation through a composite score of multiple biological measures, and gut permeability using sugar absorption testing. Late chronotype was associated with greater metabolic syndrome burden, while circadian misalignment was associated with increased gut permeability and inflammation, an association stronger among participants with higher permeability. These patterns co-occurred with lower abundance of short-chain fatty acid-associated bacteria, and intervention-related changes in permeability corresponded with changes in these taxa. These findings link circadian phenotypes with gut barrier and microbial features relevant to metabolic risk in obesity.