The Journal of Clinical Endocrinology & Metabolism

OCT 19, 2026 · JOURNAL ARTICLE

Impact of setmelanotide on metabolic syndrome risk in patients with proopiomelanocortin or leptin receptor deficiencies

The Journal of Clinical Endocrinology & Metabolism

Abstract Introduction Patients with severe obesity due to proopiomelanocortin (POMC) or leptin receptor (LEPR) deficiencies resulting in impaired melanocortin-4 receptor (MC4R) sig

OCT 9, 2026 · JOURNAL ARTICLE

Preconception incretin therapy reduces pregnancy and cardiometabolic outcomes in polycystic ovary syndrome

The Journal of Clinical Endocrinology & Metabolism

Abstract Background Polycystic ovary syndrome (PCOS), now polyendocrine metabolic ovarian syndrome (PMOS), is associated with reproductive and cardiometabolic complications. Glucag

AUG 14, 2026 · JOURNAL ARTICLE

Precision Medicine in patients with rare forms of genetic obesity: Necessity for coordinated and structured care

The Journal of Clinical Endocrinology & Metabolism

European expert consensus recommendation for structured care and centres of expertise in rare monogenic obesity, addressing diagnosis, access, and monitoring for newly approved MC4R agonist therapies.

AUG 14, 2026 · JOURNAL ARTICLE

Data-Driven Diabetes Clustering in East Asians: Pathological Heterogeneity and Personalized Medicine

The Journal of Clinical Endocrinology & Metabolism

A narrative mini-review synthesizing meta-analytic evidence on diabetes clustering in East Asians, proposing subtype-guided clinical strategies without presenting new primary data or a systematic methodology.

AUG 11, 2026 · JOURNAL ARTICLE

Temple syndrome – an under-recognised multi-system growth disorder: large cohort analysis and proposed scoring system

The Journal of Clinical Endocrinology & Metabolism

Large descriptive cohort establishing clinical phenotype and proposing a novel diagnostic scoring system, but lacking a control group, prospective validation of the score, or powered comparison of outcomes.