Oncoimmunology

SEP 22, 2026 · JOURNAL ARTICLE

Modular mRNA cocktail enables synergistic activation of antigen-specific T cells for cancer immunotherapy.

Oncoimmunology

mRNA-based therapeutics have demonstrated notable success in SARS-CoV-2 vaccines and are emerging in cancer immunotherapy. However, conventional mRNA cancer vaccines are limited in

SEP 17, 2026 · JOURNAL ARTICLE

Immune checkpoint knockout screen reveals TIGIT-CD155 interaction as a significant modulator of adapter CAR-T cell function in acute myeloid leukemia.

Oncoimmunology

Chimeric antigen receptor (CAR) T cell therapy for acute myeloid leukemia (AML) faces critical challenges, including severe on-target off-tumor toxicities, antigen heterogeneity, a

SEP 2, 2026 · JOURNAL ARTICLE

A phase II multi-institutional single arm trial evaluating TG4010 vaccine plus nivolumab in non-small cell lung cancer.

Oncoimmunology

Early-phase single-arm trial terminated early due to slow accrual with only 13 enrolled patients, showing limited clinical benefit (8.3% response rate) but providing mechanistic insights into immune response that warrant further investigation.

AUG 28, 2026 · JOURNAL ARTICLE

Store-operated calcium signaling modulators improve a dendritic cell-based vaccine against melanoma.

Oncoimmunology

Mechanistic study identifying a druggable pathway in dendritic cells using small molecules; lacks clinical efficacy data, human trials, or direct therapeutic outcome measurement.

AUG 27, 2026 · JOURNAL ARTICLE

Dark matter matters: from noncoding RNA regulation to cancer immunity.

Oncoimmunology

This is a narrative review article synthesizing conceptual frameworks about noncoding RNA roles in cancer immunity; it raises questions and proposes theoretical connections rather than presenting original empirical evidence or meta-analysis of existing trials.

JUL 26, 2026 · JOURNAL ARTICLE

Characterization of persistent HPV-specific activated T cells in head and neck squamous cell carcinoma.

Oncoimmunology

Single-center mechanistic study with small sample size (n=4 for single-cell analysis) characterizing HPV-specific T-cell populations; functional validation of TCRs supports hypothesis but lacks clinical endpoint data or comparative outcome analysis.

JUN 25, 2026 · JOURNAL ARTICLE

Early neutrophil infiltration promotes TRIMELVax-induced antitumor immunity by linking local inflammation to tumor control.

Oncoimmunology

Preclinical mechanistic study identifying neutrophils as key regulators of vaccine-induced antitumor immunity with potential therapeutic implications, but requires clinical validation.

JUN 24, 2026 · JOURNAL ARTICLE

Sequential axitinib and survivin vaccination unlock curative PD-1 immunotherapy in renal carcinoma.

Oncoimmunology

Preclinical evidence in a mouse model demonstrates that a sequenced triple regimen achieves high complete response rates, but findings are not yet clinically validated and lack quantitative efficacy metrics in the abstract.