Oncoimmunology

AUG 28, 2026 · JOURNAL ARTICLE

Store-operated calcium signaling modulators improve a dendritic cell-based vaccine against melanoma.

Oncoimmunology

Mechanistic study identifying a druggable pathway in dendritic cells using small molecules; lacks clinical efficacy data, human trials, or direct therapeutic outcome measurement.

JUL 26, 2026 · JOURNAL ARTICLE

Characterization of persistent HPV-specific activated T cells in head and neck squamous cell carcinoma.

Oncoimmunology

Single-center mechanistic study with small sample size (n=4 for single-cell analysis) characterizing HPV-specific T-cell populations; functional validation of TCRs supports hypothesis but lacks clinical endpoint data or comparative outcome analysis.

JUN 25, 2026 · JOURNAL ARTICLE

Early neutrophil infiltration promotes TRIMELVax-induced antitumor immunity by linking local inflammation to tumor control.

Oncoimmunology

Preclinical mechanistic study identifying neutrophils as key regulators of vaccine-induced antitumor immunity with potential therapeutic implications, but requires clinical validation.

JUN 24, 2026 · JOURNAL ARTICLE

Sequential axitinib and survivin vaccination unlock curative PD-1 immunotherapy in renal carcinoma.

Oncoimmunology

Preclinical evidence in a mouse model demonstrates that a sequenced triple regimen achieves high complete response rates, but findings are not yet clinically validated and lack quantitative efficacy metrics in the abstract.

MAY 16, 2026 · JOURNAL ARTICLE

An orthotopic organoid-based model to study early CD8⁺ T cell dysfunction and immunotherapy response in colorectal cancer.

Oncoimmunology

Preclinical organoid-based mouse model study demonstrating proof-of-concept for CD8+ T cell dysfunction characterization and ICI responsiveness, lacking direct clinical validation or comparative efficacy trials.