Neurobiology of Aging

SEP 16, 2026 · JOURNAL ARTICLE

Neuropathology of centenarians and supercentenarians: An autopsy study.

Neurobiology of Aging

Studies of centenarians and supercentenarians provide insight into aging and substrates of cognitive impairment at the extreme limits of age. In this study, we examined pathologic

SEP 10, 2026 · JOURNAL ARTICLE

Individual Differences in Cognitive Aging Rodent Datasets (ID-CARD): A collaborative platform for behavioral analysis across the lifespan.

Neurobiology of Aging

Understanding cognitive aging requires approaches that capture individual variability while enabling integration across studies. In rodent models, behavioral data are central to th

SEP 3, 2026 · JOURNAL ARTICLE

Regional distribution of mineralized blood vessels in Alzheimer disease and clinicopathological associations: A multicenter autopsy study.

Neurobiology of Aging

Mineralized blood vessels (MBV) are a form of vascular pathology associated with cerebrovascular aging and neurodegeneration; however, their regional distribution and clinicopathol

SEP 2, 2026 · JOURNAL ARTICLE

Older adult APOE4 mice exhibit modest immunometabolic adaptation following microglial APOE2 replacement.

Neurobiology of Aging

Apolipoprotein E (APOE) genotype is the strongest genetic determinant of late-onset Alzheimer's disease (AD) risk. Of its three common isoforms, E4 increases AD risk and promotes i

AUG 22, 2026 · JOURNAL ARTICLE

Input-output curves demonstrate motor cortex hyperexcitability associated with cognitive impairment in Alzheimer's disease.

Neurobiology of Aging

A well-designed cross-sectional study with biomarker-confirmed early AD and matched controls, demonstrating a mechanistic link between motor cortical hyperexcitability and cognitive impairment, but limited by cross-sectional design and lack of longitudinal or clinical outcome validation.

JUL 30, 2026 · JOURNAL ARTICLE

Genetic architecture of Alzheimer's disease-related plasma biomarkers.

Neurobiology of Aging

Twin study establishing heritability and genetic correlations among Alzheimer's plasma biomarkers in a cognitively normal cohort, providing mechanistic insight but using surrogate biomarkers rather than clinical outcomes.

JUL 10, 2026 · JOURNAL ARTICLE

Associations among cognitive performance, VCAM-1, and GFAP in black adults: The ARCHES study.

Neurobiology of Aging

Cross-sectional analysis of biomarker interactions in a single racial group with surrogate cognitive outcomes; lacks independent replication and mechanistic validation needed to establish clinical relevance.

JUN 26, 2026 · JOURNAL ARTICLE

Systemic infections alter cortical transcriptional signatures in Alzheimer's disease.

Neurobiology of Aging

Post-mortem observational study with transcriptomic analysis identifies associations between infection status and gene expression patterns in AD brain tissue, but lacks experimental validation, longitudinal data, or causal evidence to support clinical intervention.