BACKGROUND: Obesity induced by long-term high-fat diet (HFD) consumption is closely associated with metabolic disorders and gut microbiota dysbiosis. Although plant-derived extract
Abstract BACKGROUND Obesity is a major global public health challenge. A high‐fat diet (HFD) is a key contributing factor, closely associated with gut microbiota dysbiosis. Althoug
This is a mechanistic study in a single animal model without human data, showing pathway elucidation rather than clinical evidence of efficacy or safety.
First-in-kind preclinical study in an animal model with no human data, surrogate endpoints, and acknowledged dose-optimization need; results warrant further investigation but do not yet support clinical application.