Journal of the American Chemical Society

OCT 22, 2026 · JOURNAL ARTICLE

MetallopeptiGELs: Injectable Short-Peptide Supramolecular Hydrogels Self-Assembled by Pd Nanosheets for Bioorthogonal Therapy

Journal of the American Chemical Society

Abstract Controlling the delivery of chemotherapy to the tumor site is a long-standing goal of the medical field, as it could not only enhance the anticancer activity of the treatm

OCT 9, 2026 · JOURNAL ARTICLE

X-ray-Triggered Self-Sustaining Afterglow Scaffolds with Persistent Type-I/II ROS Generation for Imaging-Guided Hypoxic Tumor Therapy

Journal of the American Chemical Society

Abstract Afterglow imaging-guided photodynamic therapy (PDT) eliminates tissue autofluorescence and enables real-time therapeutic monitoring, yet its efficacy is constrained by sha

OCT 7, 2026 · JOURNAL ARTICLE

A Latent DNA–Protein Cross-Link Agent as a Chemical Adjuvant for Photodynamic Therapy

Journal of the American Chemical Society

Abstract Photodynamic therapy (PDT) induces cell death in part through singlet oxygen (1O2)-mediated oxidation of DNA and other biomolecules. However, PDT effectiveness can be comp

SEP 30, 2026 · JOURNAL ARTICLE

Rare-Earth-Coordinated Glutamine Nanostructure-Induced “Pseudo-Overnutrition” Metabolic Therapy

Journal of the American Chemical Society

Abstract Tumor cells display a strong dependency on nutrients, yet nutrient-deprivation strategies often fail due to their metabolic plasticity and compensatory mechanisms, and can

SEP 29, 2026 · JOURNAL ARTICLE

A Common Small-Molecule Inhibitor Targeting Multiple Siglecs Associated with Immune Checkpoint Suppression of Cytotoxicity and Phagocytosis

Journal of the American Chemical Society

Abstract Immune checkpoints are key regulators of the immune system that cancer cells exploit to evade immune surveillance. While these pathways have been targeted with antibody th

SEP 28, 2026 · JOURNAL ARTICLE

Ground-State Descriptors Predict ROS Generation Efficiency and Enable Rational Design of Sonosensitizers for PROTAC-Enhanced Sono-Immunotherapy

Journal of the American Chemical Society

Abstract Sonodynamic therapy (SDT) offers deep-tissue penetration but is limited by the lack of reliable strategies to predict intersystem crossing efficiency in sonosensitizers. H

SEP 17, 2026 · JOURNAL ARTICLE

Receptor-Guided Targeted Protein Degradation Collapses Extracellular Vesicle-Driven Tumor-Stroma Crosstalk

Journal of the American Chemical Society

Abstract Extracellular vesicles (EVs) are critical mediators of tumor-stromal communication within the tumor microenvironment (TME), where reciprocal signaling between cancer cells

AUG 13, 2026 · JOURNAL ARTICLE

“Trojan”Methionine Probe Reveals PKM2as a Methionine-Sensing Protein in the mTORC1 Pathway

Journal of the American Chemical Society

This is a mechanistic study identifying PKM2 as a methionine sensor via chemoproteomic profiling and biochemical validation in cells, with therapeutic speculation but no clinical efficacy data or in vivo validation.